ARKAY STORY

ARKAY DRINKS FEEL AND TASTE EXACTLY LIKE LIQUOR IT HAS THE SAME BURN AND KICK IN MOUTH LIKE LIQUOR.

100 % ALCOHOL FREE

Since its creation ArKay the world’s first non-alcoholic liquors collection has been rapidly gaining popularity and is pleased to launch this truly unique and innovative drink to consumers world-wide looking for an alcohol-free beverage alternative. ArKay non-alcoholic liquors are for EVERYONE and can be enjoyed ANYTIME, ANYWHERE since it can be consumed all night long without any intoxicating effects – it contains zero percent alcohol, calories, carbs or sugars! Individuals with medical conditions or religious beliefs that prohibit the consumption of alcohol can enjoy the crisp, refreshing taste of ArKay non-alcoholic liquors! Straight-up, “on-the-rocks” or with your favorite mixer, anyway is a good way to ARKAY!

Check out our MOCKTAILS section for creative and classic recipes featuring ARKAY for a non-alcoholic alternative. With the tremendous response from customers and distributors around the world, we are opening ArKay, Alcohol Free Liquor Store near you soon.

 ZERO CARBS- ZERO ALCOHOL- ZERO FAT -ZERO CALORIES- ZERO GLUTEN-ZERO SUGAR- ZERO SWEETENER

100 % FRIENDLY VEGGIE – 100 % GUILT FREE-  100 % ALCOHOL FREE-  100 % SUGAR FREE- 100 % GLUTEN FREE- 100 % FAT FREE 


At cocktail parties, designated drivers, teetotalers and pregnant women often are limited to drinking soda, water or juice – options that can become incredibly monotonous. A new beverage in the market is about to shake things up and open a world of possibilities, giving everyone a chance to enjoy all the flavor of whisky with none of the alcohol, calories, sugar or sodium.

ArKay is the world’s first alcohol free liquor, which means it tastes like liquor, looks like liquor, smells like liquor, but has never been fermented or aged in a wooden cask and contains no alcohol. This version of the popular spirit is ideal for anybody who – for personal, philosophical or religious reasons – cannot drink alcohol or simply doesn’t want to indulge. IMBIBING RESPONSIBLY The liquor-flavored drink was developed by Reynald Vito Grattagliano a US Citizen and self-made scientist after five years of intense research. Currently, it is the only drink of its kind in the world. Owner and President his wife Sylvie Grattagliano wanted to market a different drink for people who like spirits but cannot drink alcohol, whatever their reason might be. INTERNATIONAL GROWTH The product was introduced to the public in 2011 and has experienced exponential demand. 1 Million People drink Arkay “Our drink is exported all around the world because we are creating something that nobody has ever done be­fore, in fact we have given people an alcohol alternative that did not exist before.” EXPONENTIAL GROWTH Although the company has only 12 employees in its headquarters in Florida. It occupies a 5,000-square-foot office space in anticipation of its imminent growth. ArKay  is setting up a network of Alcohol Free Liquor Stores ‘franchisees covering the entire United States, from Hawaii to Maine, and also the rest of the world.

About the Alcohol Free Liquor Store Established with the sole purpose of improving people’s lives through alcohol free beverages providing taste-rocking drinks, world-changing non-alcoholic liquors and drinks crafted in over 1000 crispy flavored potions and still counting. The Alcohol Free Liquor Store ™ is the pioneer of non-alcoholic liquors, beers and wine environment, and is rapidly gaining popularity worldwide with this truly unique and innovative concept. The Alcohol-free Liquor Store ™ >will offer a selection of more than 1000 Alcohol-Free liquors, cocktails, beers and wines from all over the word. For consumers worldwide looking for an alcohol-free beverage alternative The Alcohol free Liquor Store ™ will be the place to go for non-alcoholic drink shopping. Unlike regular liquors stores The Alcohol Free Liquor Store ™ isn’t constrained by strict liquor market regulations, therefore allowing stores owners to open virtually anywhere. No Liquor License Required.

About The Alcohol Substitute Self-made Scientist Reynald Vito Grattagliano has invented a non-drug molecule that mimics the effects of alcohol: without the hangover and the ill effects. Earlier last year, he revealed that he has discovered a new generation of molecule called W.A.R.M extracted from Capsaicin commonly known as Chili Pepper that mimic the sensation of the kick and burn effect of the alcohol without the regrettable side effects. The first of Reynald’s wonder drink is the “W.AR.M MOLECULE ALCOHOL SUBSTITUTE” a non-toxic, non- drug, safe and non- inebriant drink that induces the same but carries no risk of hangover, aggression, loss of control or any of the general mess that comes from hammering your liver with a toxic compound. It targets the parts of the brain that give the good effects of alcohol but not those that give the bad effects,  this ALCOHOL  SUBSTITUTE will be marketed soon as a companion to regular drinks and soft drink, and be relatively cheap to buy once produced industrially. There are NO CONCERN about the safety of the W.A.R.M molecule because it is extracted naturally from the capsaicin and it does not contain any benzodiazepine derivative or any drug of any kind, therefore the W.A.R.M molecule drink produced by The Alcohol Substitute is a non-drug alternative drink and it is not addictive.When the Alcohol Substitute drink is mixed with your drink, it is impossible to become drunk in any way of form. http://alcoholsubstitute.com/rd-application-on-beverages/ The term Alcoholism is a disease killing 2.5 million people in the US each year, but you are not alone anymore AlcoholSubstitute.com is here to help thought research and development of a safe alternative. AlcoholSubstitute.com has discovered a new generation of non-drug Alcohol Substitute that avoids drunkenness and hangovers, the main ingredient being a molecules extracted from Chili Pepper also known as  Capsaicin. We’re often asked whether there’s a cure for alcoholism Often this is by a concerned partner or friend, and sometimes it’s by someone who suffers from the disease. Like many diseases, however, the answer lies between yes and no. The problem with alcohol is that the brain doesn’t simply forget. All those days consuming alcohol mean that the brain has become used to copious amounts of alcohol in the body. This results in tolerance and so on. For more information, visit: http://alcoholsubstitute.com/the-truth-about-alcohol/ 

The big question has always been this: If the brain can be rewired to crave alcohol, can it be re-rewired to not crave it again? Almost like an undo button on a word processor. Trouble is, the brain isn’t like a word processor. Patches cannot be installed through a convenient medium (although how cool would it be to be able to upload vital information directly to the brain?), and we cannot reboot. Instead, behaviors have to be learned. For more information, visit: http://alcoholsubstitute.com/why-alcohol-substitute/ So let’s talk some food science! That painful burning associated with the consumption of a chili pepper comes from compounds known as capsaicinoids, the most well-known of which is capsaicin. (FUN FACT: Capsaicinoids are derived from the compound vanillin, which gives vanilla its delicious taste and smell.) Surprisingly, their “hotness” or “spiciness” is not a taste but rather a sensation. There are no taste buds associated with capsaicinoids. When they reach the tongue, capsaicinoids interact with a special type of protein located on the surface of nerve cells. This protein, called TRPV1, acts a sensor for the cell giving it information about the outside world. Normally, TRPV1 gets turned on by physical heat, like a fire, above 109?F (43?C). This signal will turn the nerve cell on to allow it to trigger other nerve cells that will carry the message to the brain that it has to respond to this dangerous temperature (think of it as your neurons playing telephone).  When capsaicinoids interact with TRPV1 they also turn the protein on and cause the same signal to be transmitted to the brain into thinking it is being burned even though there is no real heat present. Note: TRPV1 is actually present on nerve cells in many locations on the body so this burning sensation can be experienced elsewhere, which is why you should always wash your hands after dealing with chili peppers, especially before touching your eyes! Now that we know why peppers are hot, you might be asking yourself, “Why exactly would anyone seek out this burning sensation?” The answer to this question can be found in the way our brains are wired. Capsaicinoids trick the brain into thinking it is being burned, which is a painful experience, through the transmission of neurotransmitters. Remember, earlier when I said your neurons play telephone. Well, when your body senses pain somewhere like the tongue that message has to make it to the brain. The message is sent from the location it is initially generated to the brain through a network of neurons by talking to each other via neurotransmitters, which are essentially chemical messages. One such message produced by capsaicinoids is substance P, which transmits pain signals. The brain responds by releasing another type of neurotransmitter known as endorphins. Endorphins are the body’s natural way of relieving pain by blocking the nerve’s ability to transmit pain signals. Additionally, the neurotransmitter dopamine, responsible for a sense of reward and pleasure, is also released. In essence, for some people eating large amounts of spicy food triggers a sense of euphoria similar to a “runner’s high”. Today AlcoholSubstitute.com is developing a method using the capsaicin molecule to fool the brain in order to make believe that this is alcohol instead, and the main ingredient is a molecules extracted from Chili Pepper also known as Capsaicin. For more information, visit: http://alcoholsubstitute.com/rd-application-on-beverages/

If The Alcohol Substitute can produce industrially an alcohol substitute which is not a drug, which is transparent and odorless like water and that can be mixed to any soft drinks or any non-alcoholic drink recipes, we will solve a worldwide social problem and become the global leader once the product hit the market with direct economic benefits for the company. To achieve our goal we need to purchase sophisticated laboratory equipment to extract the capsaicin molecule in order to create a new one that will have the same effect on the brain than alcohol, but without the addiction, the hangover and the ill effects. If you read more about capsaicin beside the burning effect it also gives a light euphoric effect that does not impair your senses but really makes you feel better and happier.

                          Fund The Fight  

Help The  to find all the resources they need for R& D. Donate to fight alcoholism today, you can make a difference in the lives of alcoholic patients and at the same time helping your community “no more DUI’s, no more intoxicated persons and less crimes.” All these reasons are why we need to fund this project and we are asking for donations to help us find an alternative to the problem. AlcoholSubstitute.com is searching non-stop for a better and safe alternative to alcohol, and our mission will always be to save lives by keeping peoples away from liquors.

Warning: The W.A.R.M Molecule is not a medicine, it is not a treatment to cure alcoholism and does not pretend to be.  

DON’T DRINK AND DRIVE UNLESS IT’S ARKAY!

 

FDA Domestic USA Registration Number: 16851493776| FDA Food Facility Registration in Mexico: 18917699142

INVESTING IN ARKAY

ArKay Beverages Ltd welcomes your involvement!

Request our private placement memorandum at  Management@ArkayGlobal.com

Thank you to contact ARKAY BEVERAGES LTD

4 th Floor Harbour centre Po Box 61 Grand Cayman, GC KY1-1102 Cayman Islands


How Much Does Pharmaceutical Innovation Cost?

A Look At 100 Companies

Matthew Herper ,  

FORBES STAFF 

I cover science and medicine, and believe this is biology’s century.  

Opinions expressed by Forbes Contributors are their own.

Money 

No factor defines success and failure for a drug company more than this: Companies that invent more, better drugs at a lower cost do better than those that hemorrhage cash but never get an important product to market. Yet 19 in 20 medicines in experimental development fail, meaning a great many companies fail too.

For years, researchers, including one team from Tufts University and another at Eli Lilly, have estimated the cost of inventing and developing a drug at $1 billion or more. These estimates try to exclude costs not directly related to a drug’s approval and also don’t allow for any comparisons between companies. Last year, for the first time, I did something far cruder: I took the 15-year research spending of a group of big pharmaceutical companies and divided it by the number of new drugs (technically new molecular entities, the Food and Drug Administration’s term for drug molecules that have not been approved in any form for any use previously).

My conclusions based on this data are here:  How The Staggering Cost Of Inventing New Drugs Is Shaping The Future Of Medicine.

How Much They Cost: R&D Spending Per New Drug

Company Number of new drugs 10 year R&D spending ($MIL) R&D per drug ($MIL)
1 Abbott 1 13183 13183
2 Sanofi 6 60768 10128
3 AstraZeneca 4 38245 9561
4 Hoffmann-La Roche 8 70928 8866
5 Pfizer 10 77786 7779
6 Wyeth 3 22702 7567
7 Eli Lilly 4 26710 6678
8 Bayer 5 33118 6624
9 Schering-Plough 3 18845 6282
10 Novartis 10 60727 6073
11 Takeda 4 24132 6033
12 Merck&Co 9 49133 5459
13 GlaxoSmithKline 11 57595 5236
14 J&J 13 67624 5202
15 Novo Nordisk 2 9251 4625
16 UCB 1 4325 4325
17 Yamanouchi 1 4321 4321
18 Fujisawa 1 4286 4286
19 Amgen 5 21350 4270
20 Astellas 3 12582 4194
21 Shionogi 1 3854 3854
22 Celgene 2 7193 3596
23 Bristol-Myers Squibb 9 30352 3372
24 Eisai 4 11534 2883
25 Teva 2 5763 2881
26 Biogen Idec 4 9470 2368
27 Vertex 2 4140 2070
28 Sunovion 1 1967 1967
29 Human Genome Sciences 1 1954 1954
30 Elan 1 1903 1903
31 Gilead 3 5527 1842
32 Exelixis 1 1789 1789
33 Lundbeck 2 3527 1763
34 Millennium 1 1593 1593
35 Genentech 4 6277 1569
36 Allergan 1 1559 1559
37 Baxter 3 4627 1542
38 Ipsen 1 1459 1459
39 Forest 4 5184 1296
40 Cephalon 1 1221 1221
41 Onyx 1 1219 1219
42 Sepracor 1 1170 1170
43 Alcon 1 1133 1133
44 Theravance 1 1010 1010
45 Genzyme 5 4814 963
46 Shire 4 3827 957
47 Arena 1 934 934
48 Watson 1 930 930
49 Adolor 1 877 877
50 Valeant 1 844 844
51 Schwarz 2 1545 772
52 NPS 1 756 756
53 Regeneron 3 2149 716
54 Affymax 1 660 660
55 Seattle Genetics 1 610 610
56 CV Therapeutics 1 599 599
57 ImClone 1 517 517
58 Dendreon 1 509 509
59 Alexion 1 490 490
60 The Medicines Company 1 455 455
61 Ariad 1 444 444
62 OSI 1 402 402
63 Talecris 1 396 396
64 Progenics 1 356 356
65 Actelion 1 346 346
66 Savient 1 339 339
67 Praecis 1 311 311
68 Vivus 1 309 309
69 MGI 1 294 294
70 Vicuron 1 286 286
71 Salix 2 560 280
72 Idenix 1 280 280
73 Mylan 3 762 254
74 Discovery Laboratories 1 228 228
75 Indevus 1 222 222
76 Cubist 1 220 220
77 Acorda 1 185 185
78 Ista 1 171 171
79 Optimer 1 171 171
80 Theratechnologies 1 164 164
81 MediGene 1 155 155
82 Vanda 1 150 150
83 Eyetech 1 144 144
84 ThromboGenics 1 137 137
85 BioMarin 3 403 134
86 Protalix 1 125 125
87 Amarin 1 122 122
88 Insmed 1 118 118
89 NeurogesX 1 89 89
90 Hyperion 1 87 87
91 Cypress Bioscience 1 82 82
92 New River 1 79 79
93 Aegerion 1 74 74
94 Sucampo 1 62 62
95 Fibrocell 1 62 62
96 Tercica 1 49 49
97 Pharmion 1 47 47
98 Kamada 1 37 37
99 Lev 1 26 26
100 OMRIX 1 15 15

This method admittedly has flaws. For Abbott Laboratories (now AbbVie) and Johnson & Johnson, it includes research spent on medical devices, not just drugs. And some of the research budget goes to safety monitoring for any big company. But the effort was well-received and useful enough that I thought it worth repeating. This time, though, I wanted to get at a slightly different question, too. What would happen if I looked at a bigger universe of companies, including those who had only launched a single product? These data would give information not about the total research spending for a successful drug, but on the amount spent on individual drugs that succeed, without failures lumped in.

Once again, the data on new drug approvals come from Bernard Munos at the Innothink Center for Research in Biomedical Innovation; the R&D data are from filings with the Securities and Exchange Commission as collected by FactSet Systems. This time, I used a fixed ten year period for drug approvals, but calculated 10-year R&D spending for the period ending a year before the most recent approval, in order to try to capture the spending on an experimental drug. The numbers were not inflation adjusted. All of these differences would tend to make numbers lower than last year, but they still end up being stunningly high. This creates a database of 98 companies who have collectively brought to market 220 drugs.

For companies that have launched more than three drugs, the median cost per new drug is $4.2 billion; for those that have launched more than four, it is $5.3 billion. Even if a company only develops one drug, the median spending is still a hefty $351 million. Note that companies with extremely low R&D spending per drug mostly get there in part by convincing a partner, usually a large pharmaceutical company, to carry the cost. Although I’d also caution against comparisons between individual companies because small differences in luck can have a big impact on numbers, these data can be useful. Bristol-Myers Squibb, for instance, looks far more efficient than its big pharma peers.”

Alcohol Substitute is not a pharmaceutical company and most of the equipment we use and the researchers that are working on the project are the same as the ones working on discovering new drugs.  So far millions of dollars has been spend to work on the W.A.R.M molecule which evidently has an impact on the cost of the drink that is now marketed by Arkay.

When purchase one Arkay bottle something around 50 % of its cost goes to research and development , while the balance is for direct cost of goods, transportation and marketing.

Fund The Fight

 

Help  to find all the resources  needed for R&D.

 

 

Donate to fight alcoholism today, you can make a difference in the lives of alcoholic people and at the same time helping your community no more DUI’s, no more intoxicated persons and less crimes.

All these reasons are why we need to fund this project and we are asking for donations to help us find an alternative to the problem.

AlcoholSubstitute.com is searching non-stop for a better and safe alternative to alcohol, and our mission will always be to save lives by keeping peoples away from liquors.

 Donate Now ! You will be directed to our paypal account